支氣管哮喘英文版課件

單擊此處編輯母版標(biāo)題樣式,單擊此處編輯母版文本樣式,第二級(jí),第三級(jí),第四級(jí),第五級(jí),*,,*,,Bronchial asthma,Department of respiration,Kong lingfei,,Bronchial asthma,1,,Asthma i human killer/,,Asthma i human killer/,2,,Background of asthma,Prevalence in the world: 1.6 hundred million,in China:1-3,in Shenyang: 1.24 %(1999),GINA: Global Initiative for Asthma (1994,WHO /HLBI,Bronchial asthmatic diagnosis guideline( 1997,Chinese medical academy,,Background of asthma,3,,Definitions of asthma,Chronic airway inflammation,Broncho-hyperresponsiveness BHR,Airflow limitation,,Definitions of asthma,4,,Mechanism: allergy theory,antigen,antigen,atopy→ IgE antibody→ mast cells., basophils,histamine,inflammatory mediaLTs,PAF,ECP,immediate asthmatic reaction, IAR,bronchial smooth muscle spasm,airway narrow,,Mechanism: allergy theory,5,,Mechanism: never-receptor disorder theory,adrenergic and cholinergic nerous systems, AC,non-adrenergic and non-cholinergic nerous systems, NANC,AC: al-receptor, MI, M3-receptors ) excitement,NANC: PS-receptor,bronchial smooth muscle contraction,AC:β receptor、 M2-receptor,excitement,NANC: VIP receptor,bronchial smooth muscle dilation,asthmatic airway:al、M1、M3、PS↑/β、M2、VP,,Mechanism: never-receptor diso,6,,Mechanism: airway inflammation theory,antigen,allergic airway inflammation AAI,ECP,MBP,inflammatory cells inflammatory mediaLTs,EOS,PAF,neutrophils,late asthmatic reaction. LAR,Tlymphocyte(Thi/Th2D),Th2 cytokine Il3、4、5, GM-CSF→lgE↑,,Mechanism: airway inflammation,7,,Differ mechanisms in acute and chronic asthma,acute,chronic,inflammation,inflammation,remodelling,bronchial contraction,inflammation cells↑,cell proliferation,mucous edema,epithelium injury,airway secretion↑,excellular base↑,aIrway,aIrway narrow→,BHR↑,reversibility↓,symptoms,exacerbation,,Differ mechanisms in acute and,8,,Other mechanisms: induced factors,Allergen: pollen, acarus,infection: virus or mycoplasmal infection,climate and physical and chemical factors,drugs: aspirin induced asthma, AIA,β- receptor inhibitor,heredity,Gastroesophageal reflux disease GERD,Psychological, incretion factors, sports,,Other mechanisms: induced fact,9,,Diagnosis standards of asthma,symptoms,signs,recovered ways,except other cardiac and pulmonary diseases,lung function examination untypical asthma,,Diagnosis standards of asthma,10,,支氣管哮喘英文版課件,11,,支氣管哮喘英文版課件,12,,支氣管哮喘英文版課件,13,,支氣管哮喘英文版課件,14,,支氣管哮喘英文版課件,15,,支氣管哮喘英文版課件,16,,支氣管哮喘英文版課件,17,,支氣管哮喘英文版課件,18,,支氣管哮喘英文版課件,19,,支氣管哮喘英文版課件,20,,支氣管哮喘英文版課件,21,,支氣管哮喘英文版課件,22,,支氣管哮喘英文版課件,23,,支氣管哮喘英文版課件,24,,支氣管哮喘英文版課件,25,,支氣管哮喘英文版課件,26,,支氣管哮喘英文版課件,27,,支氣管哮喘英文版課件,28,,支氣管哮喘英文版課件,29,,支氣管哮喘英文版課件,30,,支氣管哮喘英文版課件,31,,支氣管哮喘英文版課件,32,,支氣管哮喘英文版課件,33,,支氣管哮喘英文版課件,34,,支氣管哮喘英文版課件,35,,支氣管哮喘英文版課件,36,,支氣管哮喘英文版課件,37,,支氣管哮喘英文版課件,38,,支氣管哮喘英文版課件,39,,支氣管哮喘英文版課件,40,,支氣管哮喘英文版課件,41,